14^th Annual Conference on Stem Cell and Biomaterials March 18-19, 2020 Paris, France

Biography:

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Biography:

Shalini TV has completed MD in Ayurveda at the age of 27 years from Rajiv Gandhi University of Health Sciences, Karnataka, India. She is currently working as Research Associate in Ramaiah Indic Specialty Ayurveda, an Ayurveda treatment centre and Research Organisation. She has published around 6 papers in reputed Journals. She is also a part time practitioner of Ayurveda.

Abstract:

Prakriti (body –mind constitution of an individual) is a conventional, customized and unique the understanding of which is essential for the personalized medicine described in Ayurveda, Indian System of Medicine. Based on the Doshas( functional, bio humoral unit in the body) individuals are categorized into three major prakriti- Vata, Pitta and Kapha. The human gut micro biome hosts plenty of highly diverse and metabolically active microorganisms, mainly dominated by the bacteria, which are known to influence the physiology of an individual. Few researches have shown the correlation between the prakriti and the biochemical parameters. In this study, an attempt was made to explore any correlation between the prakriti (phenotype of an individual) with the Genetic makeup of the gut micro biome in healthy individuals.

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Biography:

Dr. Kavitha Kandiah is working as a UGC-Dr.D.S.Kothari postdoctoral fellow in Actinolaboratry, Microbiology department, Periyar University, Tamil Nadu, Salem, India. Currently, she is working on the development of Nanocomposite materials for diverse field of biomedical application. She has received many laurels and awards such as, Best women researcher award and Best Young Researcher award on 2016 and 2017 respectively. She has credit to 18 research papers in reputed International journals with total 212 Citations and Cumulative IF of 43.242 and attended 20 National and International Conferences

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Graphene oxide (GO) reduction, in particularly, the simple, cost effective and environmental benign microbial method attracts high over the other methods. Extracellular mediated actinobacterial reduction of nano graphene oxide is focused for the high purity and productivity of the product without any toxicity. In addition, Indian plant Cynodon dactylon also have an excellent ability to reduce the GO. Reduction of the nano-graphene oxide (nGO) to graphene nanoparticles (nRGO) was identified by visual colour change from brown to black. Further, the reduction of nGO into nRGO was confirmed through XRD pattern. Fig. 1 shows the disappearance of the peak at 2θ = 10° in the GO and formation of new broad peak at 2θ = 26° (JCPDS no. 411487) supports that the GO is completely reduced into graphene. The average Crystallite size of rGO is 8-10nm (Scherrer’s equation).  Further the bioactivity of biological reduced nano graphene give the superior results compare than the chemically synthesized particles. Appropriate degradation as well as HAp layer formation supports the biological synthesis and suggests for the fruitful outcome for therapeutical applications

Biography:

L. Yazgı Alyazıcı has completed her BSc on Molecular Biology and Genetics at İstanbul University. She is now a master student at Yeditepe University, Biotechnology Department. She is conducting two different projects simultaneously: Mesenchymal Stem Cell Expansion and Pathogen Box Identifiation in Hematopoietic Stem Cells. She also participated in different projets at her lab, including; Cardiogenic Regeneration, Hematopoietic Stem Cell Expansion, Gene Silencing with siRNA. She is currently the laboratory manager at Regenerative Biology lab., supervised by Assoc. Prof. Fatih Kocabaş.

Abstract:

Mesenchymal stem cells are present in the adult body, they can self-renew themselves and exhibit multipotency. They can differentiate to bone, fat, chondrocyte, and other various cell types under specific conditions. They are a great candidate for transplantation-based therapies with their immunomodulatory abilities, differentiation potentials and because of their easy accessibility.  They can be obtained from different tissue types including; bone marrow, adipose tissue, umbilical cord etc. Isolation of MSC is easy but there are major challenges on mobilization, expansion, understanding the differentiation mechanism. If these challenges overcame, MSCs show great potential for experimental and clinical applications. In our study we focused on expansion of mouse bone marrow-MSCs, with small molecule treatment. We selected the effective molecules conducting WST-1 assay, pyronin y/hoechst staining, cell cycle analysis, apoptosis analysis and settled on four different molecules. Our first and most effective molecule is a GSK-3 inhibitor that stabilizes free cytosolic β-catenin and inhibits differentiation. Second one is a p38-MAPK inhibitor. Our goal after this study is to carry this knowledge to therapeutic field

Biography:

Imad M. MOHAMED TAHIR  was born in Mosel city in 1983. After receiving primary education in Mosel and Karama town, he graduated from secondary school in IRAQ. He received a B.Sc. in chemistry science (2007) from Mosel University. Later, He completed M.A postgraduate programme in organic chemistry at Bingol University, Turkey. He is working in Quality control in Zakho District of the Dohuk Governorate of Iraqi Kurdistan as well as luctrar in Duhok university.

Abstract:

Since 1968, BODIPY dyes have been widely used as fluorescence compounds in many applications due to their high absorption coefficient, fluorescence quantum yield, and good photochemical stability as well as other beneficial properties, such as the ability to be unaffected by the pH and polarity of the environment in which they are placed, which enables them to remain stable for long periods of time. However, BODIPY cores are hydrophobic; thus, they impede labeling in biological situations. Solubility in water is critical if fluorescent probes are to be used in biological conditions. The application of probes in molecular situations is also deterred by quenching or aggressiveness in water. Thus, it is important to develop a new water-soluble BODIPY dye using spectroscopic methods. The study aimed to synthesize a new water-soluble BODIPY dye by introducing quaternary ammonium groups into the BODIPY core. The water-soluble BODIPY dye containing quaternary ammonium groups was created by introducing the water-solubilizing groups onto the meso position followed by formation of the quaternary ammonium groups using methyl iodide or 1,3-propanesultone. new and competent technique was extended and optimized for the successful synthesis of water-soluble BODIPY dyes via introducing hydrophilic groups. Moreover, with the aid of this new methodology, various derivatives of water-soluble BODIPY dyes were synthesized in moderate to good yields under mild reactions conditions. In addition, the proposed dye was verified to be soluble in water. The BODIPY water-soluble dyes present application potentials in cell imaging, labelling of bio-macromolecules, chemosensors, pH indicators, and photodynamic therapy. It is a general feeling that for them to be effective in application their optical properties and biocompatibility need to be enhanced and optimized by robust molecular design. In addition, we believe that our target BODIPY dye can also offer future application potential in the determination generally used to avert foods browning and as antioxidant and antibacterial in beverages (wine).

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Biography:

Prof. Nguyen Thanh Liem is the Director of Vinmec research institute of Stem cell and gene technology, a leading organization studies regenerative medicine in Vietnam. He is a pioneer and innovator in pediatric endoscopic surgery and stem cell transplatation for unet diseases such as bronchopulmonary dysplasia, autism, liver cirrhosis and cerebral pals in Vietnam. He has published more than 75 studies on the international journal s and has been serving as an editorial board member of some journals. He has been awared the 2018 Nikkei Asia Prize in Science and Technology.

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Roni Lara Moya has completed his studies in Biomedicine from the University of Mogi das Cruzes, Sao Paulo. He has obtained his specialization in Anti-Aging Medicine from Seville University, Spain. He completed his Master of Science in Molecular and Cellular Immunology and Biology from the University of Coimbra, Portugal and Master of Science in Clinical Advanced Nutrition from the University of Barcelona, Spain. He completed his PhD in Biomedicine and Immunology from the Gulbenkian Institute of Science and Coimbra University. He is the Coordinator of Orthomolecular Medicine of ReGenera Research Group for Aging Intervention. He is the Professor and Director of the Graduation Program in Orthomolecular Therapy - CESPU University, Portugal. He is the Scientific Advisor for Nutraceuticals and Cell Therapy Companies in Europe.

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Metastatic cancer is often a fatal disease with low survival rate that in a course of its progression implies a pathogenic cascade involving inflammation, overexpression of reactive oxygen species, loss of DNA repair, genome instability, neoangiogenesis, epithelial infiltration, collagen destruction, and immunosuppression and apoptosis evasion by cancer cells. Understanding the cross-interaction mechanism between the immune co-stimulatory and inhibitory molecules on one side and tumors cells is a key point in the development of a successful immunotherapeutic strategy to fight aggressive cancers. The active specific immunotherapy (ASI) and the GC protein macrophage activating factor (GcMAF) are two immunotherapies capable of modulating the innate and adaptive immunity against cancer. The aim of this talk is to present a case of an invasive metastatic carcinoma treated with ASI and GcMAF Forte and discusses the potentials of the individualized immunotherapy in advanced forms of cancer. Immunotherapy improves status of immune system and as a result it increases patient’s life span (and probably survival rate). In conclusion, the ASI and GcMAF Forte may offer a promising prospective immunological biomedical approach to boost immunity and enhance life expectancy in patients with metastatic cancer.

Biography:

`Mahdi Lotfipanah is an MSc top student in Medical Library and Information Sciences at Tehran University of Medical Sciences and Librarian of Royan Institute for Stem Cell Biology and Technology for more than 13 years. He is the Protocol Manager of ROYAN Congress and Award and Executive Member in Cell Journal which is an ISI journal in Cell Biology (IF: 2.363). He has some experience and scientific collaboration with epidemiology group of ROYAN Institute. He has published more than 4 papers in reputed journals. In 2016, he got the crystal statue of the best student in the university. He has many papers in the field of Library and Information Sciences in Persian language. He participated in congresses for Illustrated Evaluation of Scientific Productions before.

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