Stem Cell and Biomaterials

The aim of this study was to evaluate the effectiveness of transplantation of autologous bone marrow mononuclear cells (BMMCs) for improving gross motor function and muscle tone in children with Cerebral Palsy (CP) related to neonatal icterus.This open-label, uncontrolled clinical trial, which included 25 patients with CP related to neonatal icterus who had a Gross Motor Function Classification System (GMFCS) score between level II and level V, was conducted between July 2014 and July 2017 at Vinmec International Hospital (Vietnam). BMMCs were harvested from the patients’ iliac crests. Two BMNMC transplantations via the intrathecal route were performed: the first transplantation was performed at baseline, and the second transplantation was performed 6 months after the first transplantation. Gross motor function was measured at baseline, 6 months, and 12 months using the Gross Motor Function Measure (GMFM) and the Modified Ashworth Scale was used to measure the improvement of muscle spasticity.