14^th Annual Conference on Stem Cell and Biomaterials March 18-19, 2020 Paris, France

There is a market growth of more than US$ 149.17 Billion by 2021 at a CAGR of 16% in the given forecast period of biomaterials global market is expected. Growing of geriatric inhabitants worldwide, increase in incidence of diseases, graft transplant surgeries; medical implants and technological advancements will drive the market growth. Adverse reactions of biomaterials and strict regulatory requirements are the hampering factors favouring the market growth. Biomaterials market includes major driving factors like increase in demand of dental demands, increase in knee and hip replacement surgeries, research interest and development of biomaterials and advancement in medical innovation. Biomaterials is also having a high demand in wound healing technology and in surgeries.

By definition, Nanomaterials are materials of that wich  is sized between 1 to 100 nm. Nanomedicine is the exponentially growing within the last decades. An application of technology to health is the the main idea of Nanomedicine. Multifunctional Bionanomaterials are developing for applications like drug delivery, biosensing, and bioengineering. Nanoparticles that possess distinctive properties that build them helpful in biological applications like Drug Delivery, Regenerative medicine are known as as Bio-Nanomaterials. These materials are exploring for numerous medicine applications like tissue engineering, and biosensors. The necessity of size and biocompatibility created researchers to explore a lot of regarding Bionanomaterials for developing more distinctive purposeful properties to use them in medicine applications. There are differing types of Bionanomaterials like Metal based mostly Bionanomaterials, Metal Oxide-Based Bio-Nanomaterials, and Semiconductor-Based Bionanomaterials.

Cardiovascular Biomaterial is presently having an excellent demand and investment within the field of medicine. Biocompactibilty is the main criteria for cardiovascular biomaterials. Surface modification strategies are presently used methods for increasing the compactibility of biomaterials. The scope of cardiovascular biomaterials is growing gradually and much of recent investigators and researchers are developing interest towards this field. Two vital considerations for cardiovascular biomaterials are physical & mechanical properties and biocompactibility. Metallic and polymeric materials show a higher replacement in cardiac tissues, however they fail in case of biological tissues. Metals and their alloys, polymers and biological materials are the cardiovascular application of biomaterials.

Getting cell therapy product onto the market as quickly as possible still remains a key driver within the improvement of recombinant therapeutic proteins. Any such advance in bioprocessing is of specific interest to the industry if it significantly shortens the event timeline or improves the end product. within the monoclonal antibody (MAb) area, platform procedures have allowed companies to manage on specific mammalian cell lines, transfection approaches, process conditions and additionally downstream processing to shorten the development timeline.

3D-Bioprinting is a technique during which 3D-printing is employed to mix cells,growth growth factors and in fabrication of biomaterial components. Generally in bioinks ,3D printing uses layer by layer methodology to deposit materials and make tissue like structures that are later utilized in medical and tissue engineering fields. Biomaterials is currently rising innovations for bioprinting of cells .Bioprinting covers a large vary of biomaterials.3D-printing is showing its profound utility in analysis and in regenerative medicine. additionally there is printing of scaffolds that are happening through bioprinting and these scaffolds are used to regenerate joints and ligaments. Biomaterials like metal, ceramics, polymers and composites are presently used biomaterials in 3D-bioprinting.

Bioengineering can be defined as a discipline that applies engineering principles of design and analysis to biological systems and biomedical technologies. Examples of this technology  include bacteria engineered to produce chemicals, new medical imaging technology, portable disease diagnostic devices, and tissue engineered organs. bioengineering overlaps considerably with biotechnology and also the biomedical sciences in a way analogous to however various other varieties of engineering and technology relate to various other sciences.

Biophotonics is that the subject that deals with the study of optical procedures in biological systems, composed those that occur naturally and in bioengineered materials. The vital feature of this field is imaging and detection of cells and tissue. It additionally contains injecting fluorescent markers into a biological system to trace cell dynamics and drug delivery. Biophotonics is equally used to study biological materials or materials with assets like biological material, i.e., scattering material, on a microscopic or macroscopic scale. On the microscopic scale common applications encompass research and optical coherence tomography. On the macroscopic scale, the light is diffuse and applications ordinarily manage diffuse of optical imaging and tomography. Biomedical optics accents on the design and application of advanced optical techniques to resolve issues in medicine and biology.

The development of targeted genome editing technique using custom-engineered sequence-specific nucleases(including CRISPR/Cas9) allowed genetic changes with larger exactness. this method contains a widespread application within the reprogramming of stem cells to review disease outcomes. The fast evolution of these two techniques over years and their relationship with each other has made-up the way for understanding cellular interactions and regulation of transcription at a molecular level with considerable potency and flexibility.

 Biomaterials are substances that act and react with the biological system either as a section of medical device or as a part to interchange or repair any damaged organs or tissues. Biomaterials are often derived either naturally or synthetically. Natural Biomaterials are silk, gelatin, etc. whereas the artificial ones are the various polymers. Bioceramics like  Bio glass, alumina ,oxide are used for repairing damaged parts of musculoskeletal system and additionally utilized in dental and orthopaedic fields. Biocomposites are designed by using resin and natural fibers. It is non-wood natural fibers (rice, wheat, coconut, etc.) or wood fibers (magazines, soft and arduous woods). Metals are main alternative for biomaterials in fields of dental, orthopaedic, cardiac implants. As metals will result in wear, corrosion, therefore surface coating and modification of metals are necessary for medical applications.

Computational biology is a department of biology associated with the software of computer systems and technological ability to the information and modeling of the systems and processes of existence. As a way to precisely decipher these techniques at a molecular degree, it's so much necessary to be conscious of and study key regulatory genes and transcriptional circuits. Now a days excessive-throughput molecular profiling technology offer a strong technique to addressing these queries as they permit the profiling of tens of thousands of gene merchandise in a single experiment whereas bioinformatics is employed to interpret the data made with the help of such technologies.

Therapeutics is the branch of medication which deals with with the remedy of ailment and therefore the movement of remedial dealers. regenerative medicine, the most recent and rising branch of medical technology, deals with helpful healing of tissues or organs for the affected person affected by severe accidents or continual sickness. the outstanding progress within the subject of stem cell studies has arranged the muse for mobile primarily based cures of disease that can't be cured by using traditional medication.

Biomarkers are traceable substances that are introduced into an organism as a way to examine organ function or alternative aspects of health. For instance, rubidium chloride is employed as a radioactive isotope to evaluate insertion of muscular tissue. It can also be a substance whose detection indicates a specific disease state, for instance, the presence of an antibody might indicate an infection. Also biomarkers  indicates a change in expression or state of a protein that correlates with the chance or progression of a disease, or with the susceptibility of the disease to a given treatment.

Polymers are the macromolecules attained from various repeated subunits. Polymers are used as biomaterials and that can be of the following types, i.e., Natural Polymers: Chitosan, Collagen, Alginate. These natural polymers are used for drug delivery, wound dressing and tissue engineering. Synthetic Polymers like Polyvinylchloride (PVC),Polypropylene, Polymethyl methacrylate are used in implants, medical disposable supplies, dressings, etc. Biodegradable Biomaterials: Polyactide, Polyglycolide, etc. It is valuable as it regenerates tissue and does not leave residual traces on implantation. Mostly used for tissue screws, cartilage repair and drug delivery systems. Biopolymers are those which are established from the living organisms. Some of the examples are DNA, RNA, proteins, carbohydrates, etc. It can also be used as packaging material. Polymer composites are widely used for preparing medical implants.

Dental caries is the commonest and widespread biofilm-dependent oral disease that causes destruction of tooth structure by the acidic attack from cariogenic microorganism.It remains a difficult drawback and therefore the adult population facing this problem is enormous and despite of getting advances in caries prevention and tooth restoration,treatments still cause may be a substantial burden to tending. One of the  the most commonly used silver material in the field of dentistry is amalgam. With a rise in clinical need for dental patient,a variety of novel dental biomaterials are developed. These biomaterials should be stable and simply compactible with oral environment. The biomaterials that are in current use are zirconium oxide, resin composites, titanium alloys etc..

A biosensor can be defined as an analytical device which converts a biological response into an electrical signal. The device is formed from a electrical device associated a biological element which will be an enzyme, an antibody or a nucleic acid. The bio element interacts with the analyte being tested and also the biological response is converted into an electrical signal by the electrical device. Biosensor substrate contains three electrodes; 1) a working electrode, 2) a reference electrode and, 3) a counter electrode.

Stem cells are non-specialized cells which has the ability to become many alternative types of cells. Therefore, these cells play a key role in the body’s healing process and therefore the stem cell regenerative medicine that also as called stem cell therapy (SCT).Various types of stem cells were used to facilitate drug discovery. They can be potentially used as the disease models to treated or cure several serious or chronic illnesses. Human embryonic stem cells (ESC) may store the genetic information which can be discovering how some diseases develop. Also, the human stem cells are being used to check new drugs. By using stem cells, not only the method of drug research but its sequent path to becoming an approved drug can be accelerated.

Tissue Engineering is that the study of materials that uses the combination of cells to engineer biologically active molecules to provide well-organized tissues and organs, which may be constituted into the donor with the use of the many engineered ways together with some physicochemical factors. Biomaterial supports the built tissues physically, and guide cells by topographical and chemical signals. Regenerative medicine could be a branch of tissue engineering that deals with the method of replacing or regenerating human cells, tissues or organs to modify the standard biological perform by means that of cells, stem cells and biomaterials. Scaffolds are the materials designed to cause cellular interactions that ultimately aids in formation of latest tissues. Biomaterials helps in making new materials for tissue engineering and stem cell delivery. Bone and cartilage tissue engineering could be a quickly advancing field. New methodology of this engineering includes periodontal tissue regeneration with mesenchymal stem cells and platelet rich plasma.