Siddharth Pandey
Datt Media Products Pvt.Ltd, India
Title: Role of biodegradable polymers in bio-medical application and regenerative medicine
Biography
Biography: Siddharth Pandey
Abstract
Utilization of polymers as biomaterials has greatly impacted the advancement of modern medicine. In recent years, a wide range of natural and synthetic degradable polymers have been investigated for tissue engineering applications with novel materials constantly being developed to meet new challenges. Hemostatic products are widely used to accelerate blood clotting time in case of surgical or traumatic wounds. Severe bleeding from the wound results into loss of blood which in turn may lead to hypovolemic shock affecting tissue and organ damage. In order to stop the bleeding of wounds several active ingredients like thrombin, gelatin, collagen, fibrin, etc. are used for manufacturing hemostatic products. Our invention provides a ready to use biodegradable and biocompatible device based on chitosan and gelatin polyelectrolyte complex (PEC). The PEC is a novel porous scaffold which can be used as carrier to stop the flow of blood under surgical conditions and in other biomedical applications. The PEC scaffold is mainly impregnated with various clotting factors and clot stabilizers like thrombin, calcium chloride, glucosamine and tranexamic acid. The scaffold can be directly applied to the wound site in order to stop the bleeding with immediate results. The PEC scaffold shows very good biocompatibility, biodegradability, low toxicity and low immunogenicity at the site of injury. The preclinical studies and clinical studies data confirmed the efficacy of this product.