Pascal Janvier
University of Nantes, France
Title: Assessment of analgesic effect from drug-loaded cements using cat walk gait analysis
Biography
Biography: Pascal Janvier
Abstract
Postoperative pain following bone reconstruction is regarded as one of the major undesirable complications. This pain, which can become chronic, significantly disrupts patient recovery. However, the administration of local anesthetics has proven to be an effective analgesic technique for the treatment of postoperative pain with a significantly reduced drug use (e.g. morphine). In this clinical context, we proposed to evaluate the benefit in pain relief obtained with the defect filling by an injectable calcium phosphate cement (CPC) loaded or not with local anesthetics (bupivacaine or ropivacaine). Different formulations are prepared from a commercial CPC loaded with anesthetics. After their physicochemical characterizations, cements were implanted. Eighteen Wister female rats were operated with 0% (unloaded cement), 8% of bupivacaine and 8% ropivacaine, in a critical cylindrical defect in distal femur. To compare postoperative pain after bone filling surgery, a functional evaluation was performed using gait analysis with the Catwalk system.